XU Yingpu ¹ WANG Yu ¹ QU Fengyu ^{1, 2} WU  Xiang ¹

(1. College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025; 2. Key Laboratory of Advanced Functional Materials and Excited State of Heilongjiang Province, Harbin 150025)

Abstract:Poor water -soluble drug ibuprofen was incubated as a model drug in the 150 nm pore sized mesoporous silica nanospheres. In order to achieve a sustained release of the drug, the mesoporous silica nanospheres were tailored by different mounts of organic trimethylsilane. The assemblies were characterized by powder X -ray diffraction, Fourier transform IR spectroscopy, high-resolution transmission electron microscopy (TEM) and N₂ adsorption and desorption.

Keywords:mesoporous silica, surface modification, ibupeofen, release property